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A glance at clinical studies
Clinical development of the milk-based technology

It is readily apparent that the Ohio Survey was not a controlled study. Accordingly, Mr. Stolle hired scientists to conduct more formal investigations, including randomized, controlled clinical trials. One of the earliest of these was a double blind, placebo controlled, six-month crossover trial in subjects with rheumatoid arthritis. The study showed that there was a highly significant improvement in pain, disability, duration of morning stiffness, and reduction in medication use in people while on S100 Milk compared to conventional skim milk. This finding resulted in the issuance of a major patent and encouraged further research.

Scientists suspected that S100 Milk may also express anti-inflammatory activity, which would help explain the observed relief of arthritis symptoms. Anti-inflammatory activity was later confirmed, patented, and further investigated, and is considered a core technology in SMBI ingredients.

Numerous other clinical trials have been conducted independently on S100 Milk and ingredients over the years, many of which are published. In the cardiovascular area, LDL cholesterol lowering has been confirmed in studies conducted in Switzerland (Golay et al., 1990) and New Zealand (Sharpe et al., 1994). Blood pressure lowering was demonstrated in hypertensive patients in a cardiovascular research unit in Taiwan (Chou et al., 1992). S100 Milk also alleviated symptoms of mouth inflammation in subjects with the betel nut chewing habit in Taiwan (Tai et al., 2001). More recently, a more concentrated form of S100 Milk was developed and tested in randomized placebo-controlled trials in patients with osteoarthritis, and found to be safe and effective (Zenk et al., 2003, Colker et al., 2003). Immune support and gastrointestinal benefits were confirmed in randomized controlled clinical trials in Japan (Hattori et al., 2003). 


 

Immune today, healthy everyday.
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