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Cardiovascular health

Human Clinical Study I(18) :
Sharp et al. conducted a 38-week randomized controlled double-blind crossover trial on 30 subjects. The study consisted of five stages: a 10-week preliminary period, two 10-week treatment periods, a 4-week washout period between the treatment periods, and a 4-week post treatment period(18).

All subjects were asked to refrain from a high fat diet during the study. Subjects either drank ordinary skim milk (control group) or S100 Milk (treatment group) at 45g twice every day. Blood samples were collected in each stage. Blood pressure was also monitored and recorded. After 10-weeks of treatment, test results of the treatment group were compared with those of the control group. The results showed that S100 Milk significantly lowered cholesterol levels in the blood compared to the control group (Fig. 2). Total cholesterol levels of the S100 Milk group declined by 5.2% and LDL levels declined by 7.4%. In addition, systolic pressure and diastolic pressure in the S100 Milk group also declined by 5 mmHg and 4 mmHg, respectively (Table 2).

Fig. 2. Over time, cholesterol levels in the blood of the S100 Milk group trended lower than cholesterol levels of the control milk group(18).

  Control S100
χ±SD P value χ±SD P value
Systolic blood
pressure (mmHg)
-2.86 ± 12.94 0.236 -5.04 ± 12.65 0.037
Diastolic blood
pressure (mmHg)
-0.586 ± 7.27 0.622 -3.66 ± 6.89 0.007

Table 2. Effect of S100 Milk on reducing the diastolic pressure of hypertensive patients was better than that of the control milk group(18).



Human clinical Study II(19):
Golay et al. (1990) conducted a 24-week study on 11 subjects. After a 4-week baseline period, subjects were treated for 8-weeks with either S100 Milk (treatment group) or with ordinary skim milk (control group) followed by an 8-week period with the treatment order reversed. All subjects received 45g of skim milk powder twice each day. During the study period, changes of cholesterol levels in the blood of subjects were measured (Fig. 3). The results show that the blood of the treatment group was lower in total cholesterol levels by 8% compared with the control group, by 4% in LDL and by 8% in atherogenic index (total cholesterol/HDL cholesterol) (Table 3) .

Fig. 3. The dotted line represents total blood cholesterol of subjects consuming ordinary milk powder, while the solid line represents total blood cholesterol of subjects consuming S100 Milk. The data demonstrates that subjects consuming S100 Milk experience a decline in total cholesterol levels(19).

(skim milk from
control cows)
(skim milk from
immunized cows)
  mmol/L %
Total cholesterol 6.80 ± 1.32# 6.28 ± 1.19* 8
VLDL cholesterol 1.45 ± 1.09 1.19 ± 0.72 18
LDL cholesterol 3.96 ± 0.75 3.80 ± 0.88 4
HDL cholesterol 1.40 ± 0.41 1.37 ± 0.41 -
Total cholesterol/
HDL cholesterol
5.34 ± 1.87 4.92 ± 1.46** 8
Total triglyceride 1.65 ± 0.69 1.52 ± 0.60 8
VLDL triglyceride 1.04 ± 0.58 0.90 ± 0.50 13
LDL triglyceride 0.46 ± 0.14 0.47 ± 0.14 -
HDL triglyceride 0.15 ± 0.03 0.15 ± 0.03 -
# x ± SD of the last two measurements of each diet period.
Significantly different from placebo: *p<0.025, **p<0.05.

Table 3. The treatment group was lower than the control group by 8% with respect to total cholesterol, by 4% with respect to LDL cholesterol and by 8% with respect to atherogenic index (total cholesterol/HDL cholesterol)(19).



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