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Fig. 7. S100 MPC reduces the migration of neutrophils through vascular wall tight junctions. This anti-inflammatory mechanism helps explain its beneficial effect on arthritis symptoms and also its safety(12).

When the mechanisms of action of S100 Milk and other anti-inflammatory agents are compared, significant differences become apparent. Drugs such as glucocorticoids (e.g. cortisol) inhibit various functions of neutrophils, preventing them from inducing the symptoms associated with inflammation. Multiple mechanisms are involved in the anti-inflammatory activity of glucocorticoids: such as reducing the release of vasoactive factors, reducing the secretion of proteases and reducing the migration of neutrophils to injury sites(24).

 

Referring to data from an animal model of inflammation, Ormrod et al. (1992) discussed the effects of low molecular weight anti-inflammatory substances in S100 Milk on inflammation and the noticeable increase in the number of circulating neutrophils suggesting a decrease in overall neutrophil migration from the bloodstream. The data showed that the degree of neutrophil migration inhibition was up to 75%(12). He theorized that this anti-inflammatory component in S100 Milk may inhibit inflammatory responses by interfering with the migration of neutrophils through the vasculature. Further supporting this theory, Stelwagen et al. (1998) also demonstrated the effects of anti-inflammatory substances in immune milk on the formation and maintenance of epithelial tight junctions. He further theorized that the mechanism of these milk-derived anti-inflammatory substances is due to the reduced permeability of epithelial and vascular wall endothelial tight junctions to neutrophils resulting in less neutrophil migration into injury sites(13). Human clinical studies also showed that S100 MPC can significantly increase the number of circulating neutrophils(17); further supporting the conclusions of Ormrod and Stelwagen et al. that neutrophil migration from the bloodstream is inhibited.

Such unique anti-inflammatory mechanisms help explain the significant effects of S100 MPC on improving joint pain, stiffness and disability in human subjects, while also explaining its safety (Fig. 7).

 
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